Hyperpolarized helium-3 magnetic resonance imaging of chronic obstructive pulmonary disease exacerbation.
Journal of Magnetic Resonance Imaging : JMRI
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A chronic obstructive pulmonary disease (COPD) exsmoker underwent pulmonary function tests and hyperpolarized helium-3 ((3) He) magnetic resonance imaging (MRI) serially over 4 years, twice prior to and twice following an acute exacerbation (AE). About 2.5 years pre-AE, (3) He ventilation defect percent (VDP) was 16%, the apparent diffusion coefficient (ADC) was 0.34 cm(2) /s, and forced expiratory volume in 1 sec (FEV1 ) was 41%pred . Six months pre-AE, VDP and ADC were worse (29% and 0.38 cm(2) /s, respectively) without worsening FEV1 (47%pred ). After hospitalization and AE treatment, VDP was 20%, whereas FEV1 did not improve (45%pred ); 16 months post-AE, both VDP and ADC remained improved and similar to 4 years prior.
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This is the peer reviewed version of the following article: M Kirby, N Kanhere, R Etemad-Rezai, DG McCormack & G Parraga (2013). Hyperpolarized helium-3 magnetic resonance imaging of chronic obstructive pulmonary disease exacerbation, 37(5): 1223-1227, which has been published in final form at https://doi.org/10.1002/jmri.23896. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.