Pulmonary 3He magnetic resonance imaging biomarkers of regional airspace enlargement in alpha-1 antitrypsin deficiency

Authors

Eric Lessard
Heather M Young
Anurag Bhalla
Damien Pike
Khadija Sheikh
David G McCormack
Alexei Ouriadov
Grace Parraga

Document Type

Article

Publication Date

6-20-2017

Journal

Academic radiology

Volume

24

Issue

11

First Page

1402

Last Page

1411

URL with Digital Object Identifier

https://doi.org/10.1016/j.acra.2017.05.008

Abstract

RATIONALE AND OBJECTIVES: Thoracic x-ray computed tomography (CT) and hyperpolarized

MATERIALS AND METHODS: We enrolled patients with AATD (n = 8; 57 ± 7 years), ex-smokers with COPD (n = 8; 77 ± 6 years), and a control group of never-smokers (n = 5; 64 ± 2 years) who underwent thoracic CT, MRI, spirometry, plethysmography, the St. George's Respiratory Questionnaire, and the 6-minute walk test during a single 2-hour visit. MRI-derived ADC, L

RESULTS: In patients with AATD, there was a significantly different MRI-derived ADC (P = .03), L

CONCLUSIONS: In this proof-of-concept demonstration, we evaluated CT and MRI lung emphysema measurements and observed significantly worse MRI biomarkers of emphysema in patients with AATD compared to patients with COPD, although CT RA

Notes

This is an author-accepted manuscript of an article initially published by Elsevier. Final published version is available at: https://doi.org/10.1016/j.acra.2017.05.008

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