Pulmonary 3He magnetic resonance imaging biomarkers of regional airspace enlargement in alpha-1 antitrypsin deficiency
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RATIONALE AND OBJECTIVES: Thoracic x-ray computed tomography (CT) and hyperpolarized
MATERIALS AND METHODS: We enrolled patients with AATD (n = 8; 57 ± 7 years), ex-smokers with COPD (n = 8; 77 ± 6 years), and a control group of never-smokers (n = 5; 64 ± 2 years) who underwent thoracic CT, MRI, spirometry, plethysmography, the St. George's Respiratory Questionnaire, and the 6-minute walk test during a single 2-hour visit. MRI-derived ADC, L
RESULTS: In patients with AATD, there was a significantly different MRI-derived ADC (P = .03), L
CONCLUSIONS: In this proof-of-concept demonstration, we evaluated CT and MRI lung emphysema measurements and observed significantly worse MRI biomarkers of emphysema in patients with AATD compared to patients with COPD, although CT RA
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