Oscillometry and pulmonary MRI measurements of ventilation heterogeneity in obstructive lung disease: Relationship to quality of life and disease control

Authors

Heather M Young
Fumin Guo
Rachel L Eddy
Geoffrey Maksym
Grace Parraga

Document Type

Article

Publication Date

7-20-2018

Journal

Journal of Applied Physiology (1985)

Volume

125

Issue

1

First Page

73

Last Page

85

URL with Digital Object Identifier

https://doi.org/10.1152/japplphysiol.01031.2017

Abstract

Ventilation heterogeneity is a hallmark finding in obstructive lung disease and may be evaluated using a variety of methods, including multiple-breath gas washout and pulmonary imaging. Such methods provide an opportunity to better understand the relationships between structural and functional abnormalities in the lungs, and their relationships with important clinical outcomes. We measured ventilation heterogeneity and respiratory impedance in 100 subjects [50 patients with asthma, 22 ex-smokers, and 28 patients with chronic obstructive pulmonary disease (COPD)] using oscillometry and hyperpolarized

Notes

This article was initially published by the American Physiological Association and is available at: https://doi.org/10.1152/japplphysiol.01031.2017