Biochemistry Publications

 

Scientists in the Department of Biochemistry have expertise in genome dynamics, epigenetics, and gene expression; human genetics and clinical biochemistry; signal transduction and intracellular communication; macromolecular structure and dynamics; proteomics; and bioinformatics.

Visit the Department of Biochemistry Research website for additional information,

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Submissions from 2017

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Accurate cytogenetic biodosimetry through automated dicentric chromosome curation and metaphase cell selection, Jin Liu, Yanxin Li, Ruth Wilkins, Canadian Nuclear Laboratories, Joan H. Knoll, and Peter Rogan

Submissions from 2016

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Prioritizing Variants in Complete Hereditary Breast and Ovarian Cancer (HBOC) Genes in Patients Lacking known BRCA Mutations., Natasha G Caminsky, Eliseos J Mucaki, Ami M Perri, Ruipeng Lu, Joan H M Knoll, and Peter K Rogan

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Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning., Stephanie N Dorman, Katherina Baranova, Joan H M Knoll, Brad L Urquhart, Gabriella Mariani, Maria Luisa Carcangiu, and Peter K Rogan

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Cost-effectiveness of using a gene expression profiling test to aid in identifying the primary tumour in patients with cancer of unknown primary., M B Hannouf, E Winquist, S M Mahmud, M Brackstone, S Sarma, G Rodrigues, P Rogan, J S Hoch, and G S Zaric

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Automated discrimination of dicentric and monocentric chromosomes by machine learning-based image processing., Yanxin Li, Joan H Knoll, Ruth C Wilkins, Farrah N Flegal, and Peter K Rogan

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Domains of STIP1 responsible for regulating PrPC-dependent amyloid-β oligomer toxicity., Andrzej Maciejewski, Valeriy G Ostapchenko, Flavio H Beraldo, Vania F Prado, Marco A M Prado, and Wing-Yiu Choy

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A Unified Analytic Framework for Prioritization of Non-Coding Variants of Uncertain Significance in Heritable Breast and Ovarian Cancer, Eliseos J. Mucaki, Natasha G. Caminsky, Ami M. Perri, Ruipeng Lu, Alain Laederach, Matthew Halvorsen, Joan H. M. Knoll, and Peter K. Rogan

Submissions from 2015

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Beclin-1 Expression is Retained in High-Grade Serous Ovarian Cancer yet is Not Essential for Autophagy Induction In Vitro, Rohann J. M. Correa, Yudith Ramos Valdes, Trevor G. Shepherd, and Gabriel E. DiMattia

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Molecular effects of cancer-associated somatic mutations on the structural and target recognition properties of Keap1., Halema Khan, Ryan C Killoran, Anne Brickenden, Jingsong Fan, Daiwen Yang, and Wing-Yiu Choy

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Reversing chromatin accessibility differences that distinguish homologous mitotic metaphase chromosomes., Wahab A Khan, Peter K Rogan, and Joan H M Knoll

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Structural Analysis of the 14-3-3ζ/Chibby Interaction Involved in Wnt/β-Catenin Signaling, Ryan C Killoran, Jingsong Fan, Daiwen Yang, Brian H Shilton, and Wing-Yiu Choy

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Characterization of RanBPM Molecular Determinants that Control its Subcellular Localization, Louisa M Salemi, Sandra O Loureiro, and Caroline Schild-Poulter

Submissions from 2014

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Interpretation of mRNA splicing mutations in genetic disease: review of the literature and guidelines for information-theoretical analysis., Natasha Caminsky, Eliseos J Mucaki, and Peter K Rogan

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Splicing mutation analysis reveals previously unrecognized pathways in lymph node-invasive breast cancer., Stephanie N Dorman, Coby Viner, and Peter K Rogan

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Unifying the analysis of high-throughput sequencing datasets: characterizing RNA-seq, 16S rRNA gene sequencing and selective growth experiments by compositional data analysis., Andrew D Fernandes, Jennifer Ns Reid, Jean M Macklaim, Thomas A McMurrough, David R Edgell, and Gregory B Gloor

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Localized, non-random differences in chromatin accessibility between homologous metaphase chromosomes., Wahab A Khan, Peter K Rogan, and Joan Hm Knoll

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Automating dicentric chromosome detection from cytogenetic biodosimetry data., Peter K Rogan, Yanxin Li, Asanka Wickramasinghe, Akila Subasinghe, Natasha Caminsky, Wahab Khan, Jagath Samarabandu, Ruth Wilkins, Farrah Flegal, and Joan H Knoll

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Validation of predicted mRNA splicing mutations using high-throughput transcriptome data., Coby Viner, Stephanie N Dorman, Ben C Shirley, and Peter K Rogan

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Validation of predicted mRNA splicing mutations using high-throughput transcriptome data, Coby Viner, Stephanie Dorman, Ben Shirley, and Peter Rogan

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MegaTevs: Single-Chain Dual Nucleases for Efficient Gene Disruption, Jason M Wolfs, Matthew DaSilva, Sarah E Meister, Xu Wang, Caroline Schild-Poulter, and David R. Edgell

Submissions from 2013

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Individual Interactions of the b Subunits within the Stator of the Escherichia coli ATP Synthase., Karsten Brandt, Sarah Maiwald, Brigitte Herkenhoff-Hesselmann, Kerstin Gnirss, Joerg-Christian Greie, Stanley D Dunn, and Gabriele Deckers-Hebestreit

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Fuzzy complex formation between the intrinsically disordered prothymosin α and the Kelch domain of Keap1 involved in the oxidative stress response., Halema Khan, Elio A Cino, Anne Brickenden, Jingsong Fan, Daiwen Yang, and Wing-Yiu Choy

Submissions from 2012

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Stomatin-like protein 2 deficiency in T cells is associated with altered mitochondrial respiration and defective CD4+ T cell responses., Darah A Christie, Panagiotis Mitsopoulos, Julianna Blagih, Stanley D Dunn, Julie St-Pierre, Russell G Jones, Grant M Hatch, and Joaquín Madrenas

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(1)H, (15)N and (13)C backbone resonance assignments of the Kelch domain of mouse Keap1., Elio Cino, Jingsong Fan, Daiwen Yang, and Wing-Yiu Choy

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Elastic deformations of the rotary double motor of single F(o)F(1)-ATP synthases detected in real time by Förster resonance energy transfer., Stefan Ernst, Monika G Düser, Nawid Zarrabi, Stanley D Dunn, and Michael Börsch