Nucleotide excision repair (NER) is a vital DNA repair pathway which acts on a wide range of helix-distorting lesions. The importance of this pathway is highlighted by its functional conservation throughout evolution and by several human diseases, such as xeroderma pigmentosum, which are caused by a defective NER pathway. This review summarizes the NER mechanisms present in all three domains of life: eukaryotes, bacteria, and archaea.
Digital Object Identifier
Farnell, David A.
"Nucleotide Excision Repair in the Three Domains of Life,"
WURJ: Health and Natural Sciences: Vol. 2
, Article 1.
Available at: http://ir.lib.uwo.ca/wurjhns/vol2/iss1/1