Surgery Publications

Title

Early Steroid Withdrawal after Liver Transplantation: The Canadian Tacrolimus versus Microemulsion Cyclosporin A Trial: 1-year Follow-up

Document Type

Article

Publication Date

6-2003

Journal

Liver Transplantation

Volume

9

Issue

6

First Page

587

Last Page

595

URL with Digital Object Identifier

http://dx.doi.org/10.1053/jlts.2003.50102

Abstract

Corticosteroid therapy contributes significant toxicity to liver transplantation. The safety and efficacy of early steroid withdrawal were determined in patients treated with either tacrolimus or microemulsion cyclosporin A (micro-CsA). The primary outcome was the proportion of patients who were steroid-free 1 year posttransplantation. From the seven Canadian adult liver transplant centers, 143 patients were randomly allocated oral treatment with either tacrolimus (n = 71) or micro-CsA (n = 72), together with corticosteroids and azathioprine. Eligibility criteria for steroid withdrawal included freedom from acute rejection for a minimum of 3 months, and prednisone

Notes

Dr. Vivian McAlister is currently a faculty member at The University of Western Ontario.