Surgery Publications

Title

Feasibility Investigation of Allogeneic Endometrial Regenerative Cells

Document Type

Article

Publication Date

2-20-2009

Journal

Surgery Publications

Abstract

Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like stem cells having pluripotent differentiation activity and ability to induce neoangiogenesis. In vitro and animal studies suggest ERC are immune privileged and in certain situations actively suppress ongoing immune responses. In this paper we describe the production of clinical grade ERC and initial safety experiences in 4 patients with multiple sclerosis treated intravenously and intrathecally. The case with the longest follow up, of more than one year, revealed no immunological reactions or treatment associated adverse effects. These preliminary data suggest feasibility of clinical ERC administration and support further studies with this novel stem cell type.

Notes

Published in: Journal of Translational Medicine 2009, 7:15 (doi:10.1186/1479-5876-7-15). The electronic version of this article is the complete one and can be found online at: http://www.translational-medicine.com/content/7/1/15