Title

Human CNS Cultures Exposed to HIV-1 gp120 Reproduce Dendritic Injuries of HIV-1-associated Dementia

Document Type

Article

Publication Date

5-27-2004

Journal

Journal of Neuroinflammation

Volume

1

Issue

7

Abstract

HIV-1-associated dementia remains a common subacute to chronic central nervous system degeneration in adult and pediatric HIV-1 infected populations. A number of viral and host factors have been implicated including the HIV-1 120 kDa envelope glycoprotein (gp120). In human post-mortem studies using confocal scanning laser microscopy for microtubule-associated protein 2 and synaptophysin, neuronal dendritic pathology correlated with dementia. In the present study, primary human CNS cultures exposed to HIV-1 gp120 at 4 weeks in vitro suffered gliosis and dendritic damage analogous to that described in association with HIV-1-associated dementia.

Notes

Published in: Journal of Neuroinflammation, 2004, 1:7. doi: 10.1186/1742-2094-1-7