Pathology Theses and Dissertations
This collection contains theses and dissertations from the Department of Pathology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository
Theses/Dissertations from 2023
Investigation of Novel Pan-RAF Inhibitors in Anaplastic Thyroid Cancer, Sarah EB Ryan
Theses/Dissertations from 2022
Evaluating the utility of S100A7 in identifying oral dysplastic lesions that will progress to oral squamous cell carcinoma, Jeff Soparlo
Theses/Dissertations from 2021
Theses/Dissertations from 2020
Evidence of an Antigen Presenting Cell Phenotype in Granular Cell Tumours, Benjamin J W A Rogala
Theses/Dissertations from 2019
Junctophilin-2 Protects Cardiomyocytes against Palmitate-induced Injury, Xiaoyun Ji
Evaluating the Utility of Protein Biomarker, S100A7, and Diagnostic Test, Straticyte, in Predicting the Progression of Oral Dysplasia, Lachlan McLean
Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction, Michael G. Tauro
Theses/Dissertations from 2018
Mitochondrial permeability regulates cardiac endothelial cell necroptosis and cardiac allograft rejection, Ingrid Gan
Kallikrein-Related Peptidases are Dysregulated in Pleomorphic Adenoma, Matthew D. Morrison
Elucidating mechanisms of innate and acquired resistance to PI3Ka inhibition in head and neck squamous cell carcinoma, Kara M. Ruicci
The Effects of Child Restraint System Use and Motor Vehicle Collision Severity on Injury Patterns and Severity in Children 8 Years Old and Younger., Peyton A. Schroeder
Role of Long Noncoding RNAs in Diabetic Complications, Anu Alice Thomas
Effect of Estrogen and Glucocorticoid Signaling on Th2 cells – Implications for Severe Asthma, Meerah Vijeyakumaran
Theses/Dissertations from 2017
CRISPR Screen for Identification of Kinases that Mediate Prostate Cancer Cell Invasion, Hamad Aldhafeeri
Immunological Impact of CLI-095 on Dendritic Cell Maturation and Hypoxia-re-oxygenation induced inflammatory injury, Hajed Obaid Alharbi
ERK5 Expression in Brain Tumours, Reem Ansari
Expression of Human Tissue Kallikreins (KLKs) in Polymorphous Low Grade Adenocarcinoma (PLGA), Jacqueline M. Cox
Mechanisms underlying chemotherapy-induced vascular proliferation in ovarian cancer, Zeynep Gülsüm Kahramanoğlu
The Effect of Glucocorticosteroids on Th2 cells, Tharsan Kanagalingam
Hsp90 and its Co-chaperones Modify TDP-43 Localization, Aggregation, and Toxicity, Lilian T. Lin
Characterization of Hemangioma-initiating Stem Cells, Natalie Montwill
Postnatal β1 Integrin Deficiency in Pancreatic Beta-Cells Impairs Function and Survival, Jason E. Peart
Theses/Dissertations from 2016
Body and Organ Measurements in Infants and Neonates: An Autopsy Study, Audrey-Ann M. Evetts
The Long Non-coding RNA Malat1 Regulates Inflammatory Cytokine Production in Chronic Diabetic Complications, Andrew D. Gordon
Expression of Kallikrein-Related Peptidases (KLKs) in Adenoid Cystic Carcinoma, Zachary R. Kerr
Mechanisms regulating stem cell phenotype in infantile hemangioma, Niamh Richmond
Etiology of Motor Vehicle Collision Fatalities in Urban and Rural Canada, James R. Roos
Identification of a Nuclear Localization Signal (NLS) within the Pleckstrin Homology (PH) domain of Rho Guanine Nucleotide Exchange Factor (RGNEF), Michael V. Tavolieri
Development and Performance Evaluation of an Antibody-Based Technology for Detection of E. coli O157 in Meat Samples and Its Potential Evolution Using Antibody Engineering, Yadira Tejeda Saldaña
Theses/Dissertations from 2015
Phase II Clinical Trial of Concurrent Neoadjuvant Chemotherapy With Radiotherapy in Locally Advanced Breast Cancer, Muriel Brackstone
Expression Of Human Kallikrein Protein And mRNA In Maxillofacial Cysts And Tumours, Karl Kevin Cuddy
Chromatin Structure and Differential Accessibility of Homologous Human Mitotic Metaphase Chromosomes, Wahab A. Khan
β-adrenergic receptor-dependent and -independent effects of propranolol in infantile hemangioma, Jina J.Y. Kum
CD4+ T-cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection Involves Necroptosis, Cecilia YT Kwok
Epithelial to mesenchymal transition in the metastatic progression of gastroenteropancreatic neuroendocrine tumours, Stephanie Mok
Protective Effect of Modified Human Fibroblast Growth Factor on Diabetic Nephropathy, Ana M. Pena Diaz
Diabetic Bone Marrow & Stem Cell Dysfunction, Meghan A. Piccinin
Theses/Dissertations from 2014
The Role Of The RNA-Binding Protein Rho Guanine Nucleotide Exchange Factor In The Cellular Stress Response, Kevin WH Cheung
Exposure to Environmental Contaminants and Stress as Determinants of Health in Three Communities: Walpole Island and Attawapiskat First Nations and Naivasha, Kenya, Deirdre Phaedra Henley
miRNA Regulation of Programmed Cell Death-1 in T Cells: Potential Prognostic and Therapeutic Markers in Melanoma, Nathan J. Johnston
Cell Death Regulates Injury and Inflammation During Renal Allograft Transplantation, Arthur Lau
Role of SIRT1 in Vascular Complications of Diabetes, Rokhsana Mortuza
RIPK3 Regulates Microvascular Endothelial Cell Necroptosis and Cardiac Allograft Rejection, Alexander William Pavlosky
The Role of Integrins in Support of Pancreatic Function, Survival and Maturation, Matthew Riopel
Polycomb Repressive Complex 2 Regulates miR-200b in Retinal Endothelial Cells: Possible Implications in Diabetic Retinopathy, Michael A. Ruiz
Association of Head and Cervical Injuries in Pediatric Occupants Involved in Motor Vehicle Collisions, Shayan Shekari
Development of Non-Covalent Functionalization of Carbon Nanotubes for siRNA Delivery, King Sun Siu
Theses/Dissertations from 2013
Targeted siRNA Delivery Methods for RNAi-Based Therapies, Di Chen
Elucidating the Role of Menin During Islet Cell Development in the Human Fetal Pancreas, Jessica L. Dubrick
Vascular Stem Cells in Diabetic Complications, Emily C. Keats
Theses/Dissertations from 2012
The role of non-canonical Wnt/planar cell polarity signalling in breast cancer progression, Connor D. MacMillan
Elucidating the Function of Transplanted Islets of Langerhans and Predicting Their Ability to Reverse Diabetes, Andrew R. Pepper
Role of ERK5 in Diabetic Vascular Complications, Yuexiu Wu
Theses/Dissertations from 2011
A Model System for Rapid Identification and Functional Testing of Genes Involved in Early Breast Cancer Progression, Lesley H. Souter