Oncology Publications

Title

Hyaluronan Metabolism in Remodeling Extracellular Matrix: Probes for Imaging and Therapy of Breast Cancer

Document Type

Article

Publication Date

4-2011

Journal

Integrative Biology

Volume

3

Issue

4

First Page

304

Last Page

315

URL with Digital Object Identifier

http://dx.doi.org/10.1039/C0IB00096E

Abstract

Clinical and experimental evidence increasingly support the concept of cancer as a disease that emulates a component of wound healing, in particular abnormal stromal extracellular matrix remodeling. Here we review the biology and function of one remodeling process, hyaluronan (HA) metabolism, which is essential for wound resolution but closely linked to breast cancer (BCA) progression. Components of the HA metabolic cycle (HAS2, SPAM1 and HA receptors CD44, RHAMM/HMMR and TLR2) are discussed in terms of their known functions in wound healing and in breast cancer progression. Finally, we discuss recent advances in the use of HA-based platforms for developing nanoprobes to image areas of active HA metabolism and for therapeutics in breast cancer.