Medical Imaging Publications Copyright (c) 2013 Western University All rights reserved. http://ir.lib.uwo.ca/medimagingpub Recent documents in Medical Imaging Publications en-us Sun, 27 Jan 2013 00:30:49 PST 3600 Transbilayer Phospholipids Molecular Imaging http://ir.lib.uwo.ca/medimagingpub/1 http://ir.lib.uwo.ca/medimagingpub/1 Wed, 26 Oct 2011 19:04:41 PDT Nuclear medicine has become a key part of molecular imaging. In the present review article, we focus on the transbilayer phospholipids as exquisite targets for radiolabelled probes in molecular imaging. Asymmetry of phospholipid distribution is a characteristic of mammalian cell membranes. Phosphatidylcholine and sphyngomyelin cholinophospholipids are primarily located within the external leaflet of the cell membrane. Phosphatidylserine and phosphatidylethanolamine aminophospholipids, and also phosphatidylinositol are primarily located within the internal leaflet of the cell membrane. New radiolabelled tracers have been designed in preclinical and clinical research for PET-CT and SPECT-CT molecular imaging of transbilayer phospholipids.

]]> Tarik Z. Belhocine et al.