Title

T-cell Anergy and Altered T-cell Receptor Signaling: Effects on Autoimmune Disease

Document Type

Article

Publication Date

10-1998

Journal

Immunology Today

Volume

19

Issue

10

First Page

468

Last Page

473

URL with Digital Object Identifier

10.1016/S0167-5699(98)01326-7

Abstract

Immunological self-tolerance can be acquired by several mechanisms, including the induction of anergy in autoreactive T cells. In this sense, anergy is predictably advantageous for the immune system. Here, Konstantin Salojin and colleagues present an alternative view that the induction of anergy in regulatory T cells may be harmful to the host and elicit autoimmune disease.