Title

The Future of RIP2/RICK/CARDIAK as a Biomarker of the Inflammatory Response to Infection

Document Type

Article

Publication Date

5-2008

Journal

Expert Review of Molecular Diagnostics

Volume

8

Issue

3

First Page

257

Last Page

261

Abstract

Biological markers of disease have become increasingly important for the clinician to diagnose, predict and monitor progression, and assess the therapeutic effect of interventions on underlying pathogenic mechanisms. Robust and specific biomarkers would be very useful in inflammation, where they may facilitate early identification of tissue injury, predict disease progression and help to modify disease outcomes. However, at present, there are no robust biomarkers to predict the course of inflammation. Here, we discuss emerging data indicating that RIP2, a putative serine/threonine protein kinase, may serve as a biomarker for the resolution of peritoneal dialysis-associated peritonitis and, more generally, of the acute inflammatory response to infection.

Notes

Published in: Expert Review of Molecular Diagnostics, May 2008, Vol. 8, No. 3, Pages 257-261. DOI: 10.1586/14737159.8.3.257