Title

Clustering of a Lipid-raft Associated Pool of ERM Proteins at the Immunological Synapse upon T cell Receptor or CD28 Ligation

Document Type

Article

Publication Date

9-2-2002

Journal

Immunology Letters

Volume

83

Issue

2

First Page

143

Last Page

147

URL with Digital Object Identifier

10.1016/S0165-2478(02)00075-5

Abstract

Although ezrin is tyrosine phosphorylated following TCR ligation, its biological role in T cell activation is not known. Here, we shhow that ezrin clusters at the immunological synapse upon T cell stimulation. Clustering of ezrin can be triggered by TCR ligation, or, more efficiently, by CD28 ligation. The clusters of ezrin at the immunological synapse include serine/threonine phosphorylated ezrin predominantly located within cell membrane lipid rafts. Based on these data, we propose that ezrin may play a role in the formation/stabilization of lipid raft signalosomes at the immunological synapse and therefore contribute to sustain TCR-dependent signalling.