Title

A SLAT in the Th2 Signalosome

Document Type

Article

Publication Date

4-1-2003

Journal

Immunity

Volume

18

Issue

4

First Page

459

Last Page

461

URL with Digital Object Identifier

10.1016/S1074-7613(03)00089-X

Abstract

There is abundant information on the distinguishing features of TCR-mediated signaling in Th1 and Th2 cells. However, the primary signals that determine the commitment and differentiation of naive T cells toward those T helper subsets, especially prior to the contribution of polarizing cytokines, remain elusive. This minireview discusses the potential contribution of SLAT in favoring differentiation along the Th2 lineage and how this may bring us closer to a framework model for Th1/Th2 differentiation.