Title
Viewpoint: Therapeutic Implications of CTLA-4 Compartmentalization
Document Type
Article
Publication Date
8-2003
Journal
American Journal of Transplantation
Volume
3
Issue
8
First Page
919
Last Page
926
URL with Digital Object Identifier
10.1034/j.1600-6143.2003.00182.x
Abstract
Understanding the regulatory events involved in the activation and inactivation of T cells is crucial to develop therapeutic approaches for autoimmune diseases and for organ transplantation. Co-stimulatory signals delivered through the CD28 receptor and inhibitory signals through CTLA-4 are required for the proper modulation of T cell responses and the induction and maintenance of peripheral tolerance. Manipulation of these signals is emerging as a potential strategy to prevent allograft rejection in different animal models. Recent data on the compartmentalization and the structural features of CTLA-4 within T cells provides critical information not only on the molecular basis of T cell inactivation by CTLA-4, but also on the key requirements for the successful development of therapeutic strategies targeting this molecule.
