Title

Virus Attachment and Replication Are Promoted after Acquisition of Host CD28 and CD152 by HIV-1

Document Type

Article

Publication Date

10-1-2005

Journal

Journal of Infectious Diseases

Volume

192

Issue

7

First Page

1265

Last Page

1268

URL with Digital Object Identifier

10.1086/444426

Abstract

CD28 is constitutively expressed on CD4(+) cells, but its homologue CD152 is only weakly expressed after cell activation. To determine whether these 2 costimulatory molecules can be inserted into human immunodeficiency virus type 1 (HIV-1), virus was produced in CD28- and CD152-expressing Jurkat-derived cells. Both molecules were efficiently acquired by virions. Virus attachment and infectivity were more affected by CD152 than by CD28. Given that CD28/CD152-CD80/CD86 interactions play a dominant role in antigen presentation, it can thus be proposed that the association between virus-anchored host CD28/CD152 and cell-surface CD80/CD86 on target cells might have consequences for the transmission and pathogenesis of HIV-1.