Inspiring Minds seeks to broaden awareness and impact of graduate student research, while enhancing transferable skills. Students were challenged to describe their research, scholarship or creative activity in 150 or fewer words to share with our community.
Enhancing Study Validity through Simulated Exploration of Missing Data in Pragmatic Trials
In pragmatic trials, addressing missing data is crucial. Our investigation is similar to a detective narrative, where critical evidence disappears. Our mission? We analyze various datasets encountering different missing data scenarios, from random to non-random patterns. By simulating different rates of missing data, such as 10% or 20%, we aim to discern their impact on the treatment effect. Crucially, we seek to pinpoint the threshold at which missing data significantly compromises study reliability. Through simulated data analysis, our goal is to identify an optimal threshold, minimizing disruptions to the treatment effect while upholding study integrity. This research will provide valuable insights into the robustness of pragmatic trials in the face of missing data, ultimately enhancing the trustworthiness of real-world evidence. Additionally, by shedding light on the impact of missing data, our findings will contribute to the development of guidelines for conducting pragmatic trials, thus elevating the quality of medical research.
Bahareh Kheiri
MSc candidate, Epidemiology and Biostatistics
Schulich School of Medicine & Dentistry - Western University
Supervisors
Osvaldo Espin Garcia
Merrick Zwarenstein
Bahareh Kheiri is an MSc candidate in Epidemiology and Biostatistics at the Schulich School of Medicine & Dentistry, Western University. She holds a Bachelor of Science in Statistics from the University of Science and Culture in Tehran and a Master of Science in Biostatistics from Shahid Beheshti University of Medical Sciences. With over a decade of experience as a Project Coordinator and Data Analyst at the Ophthalmic Research Center, Bahareh has a robust background in randomized clinical trials and applied statistics. She is proficient in conducting data analysis and providing methodological consulting for various types of studies. She has served as a statistical consultant for various clinical research centers and has contributed to numerous publications. Under the supervision of Dr. Merrick Zwarenstein and Dr. Osvaldo Espin Garcia, Bahareh Kheiri is focusing her MSc studies in Epidemiology and Biostatistics on handling missing data in pragmatic trials. These activities showcase her commitment to advancing the field of epidemiology and Biostatistics through both research and education, as she actively engages in sharing knowledge and contributing to the academic community.
You can connect with Bahareh on LinkedIn or via email at bkheiri@uwo.ca.
View Bahareh's work as it appears in the Inspiring Minds Digital Collection: https://ir.lib.uwo.ca/inspiringminds/643/.