Location of Thesis Examination
Room 105 Medical Science Building
Master of Science
Epidemiology and Biostatistics
Dr Richard Malthaner
Objectives: To develop a prototype decision aid used to assist ulcerative colitis patients when deciding between ileal pouch-anal anastomosis (IPAA) and ileostomy.
Methods: Three separate systematic reviews (quality of life studies, IPAA studies, ileostomy studies) were conducted to populate the decision aid with outcome probabilities. Meta-regression was used to select appropriate pooled outcomes.
Results: Of 3920 studies reviewed, 9 studies reported on quality of life, 67 on outcomes following IPAA, and 11 following ileostomy. No difference in quality of life was found between procedures. Among IPAA patients, pooled pouch failure rate was 5.5%, with pouchitis being the most common complication (22%). Among ileostomy patients, the pooled rate of ileostomy revision was 17.1%.
Conclusions: No surgical option is clearly superior and patients must weight specific risks and benefits in deciding between procedures. This newly developed decision aid may help patients decide which option is best for them.
Dubois, Luc A., "The Development of a Decision Aid for Patients with Ulcerative Colitis Deciding Between Ileostomy or Ileal Anal-Pouch Reconstruction" (2012). University of Western Ontario - Electronic Thesis and Dissertation Repository. Paper 877.