Master of Science
Epidemiology and Biostatistics
Dr. Neil Klar / Dr. Guangyong Zou
For many-to-one comparisons of independent binomial proportions using their ratios, we propose the MOVER approach generalizing Fieller's theorem to a ratio of proportions by obtaining variance estimates in the neighbourhood of confidence limits for each proportion. We review two existing methods of inverting Wald and score test statistics and compare their performance with the proposed MOVER approach with score limits and Jeffreys limits for single proportions. As an appropriate multiplicity adjustment incorporating correlations between risk ratios, a Dunnett critical value is computed assuming a common, constant correlation of 0.5 instead of plugging in sample correlation coefficients. The simulation results suggest that the MOVER approach has desirable operating characteristics comparable to those of the method of inverting score test statistics. The MOVER with Jeffreys limits yields the median joint coverage percentage closest to the nominal level but its intervals may be wider than the other intervals in some parameter settings.
Shin, Jungwon, "Simultaneous Confidence Intervals for Risk Ratios in the Many-to-One Comparisons of Proportions" (2012). University of Western Ontario - Electronic Thesis and Dissertation Repository. Paper 709.