Degree
Doctor of Philosophy
Program
Medical Biophysics
Supervisor
Dr. Ting Lee
Abstract
The blood-brain-barrier (BBB) is the single most limiting factor in the delivery of neurotherapeutics into the brain. Focused ultrasound sonication combined with intravenous microbubble administration (FUSwMB) is a novel technique that can transiently disrupt the BBB, with minimal vascular or tissue damage, allowing for localized drug delivery over the targeted region. The goals of this thesis are to: 1) use computed tomography (CT) perfusion to measure the permeability surface area product (PS) following USwMB in normal rabbits with an intact BBB, and 2) to evaluate the blood-tumor-barrier (BTB) PS response following FUSwMB in a C6 rat glioma model.
Recommended Citation
Ahmed, Hassaan, "Using Computed Tomography Perfusion to Evaluate the Blood-Brain-Barrier and Blood-Tumor-Barrier Response following Focused Ultrasound Sonication with Microbubble Administration" (2017). Electronic Thesis and Dissertation Repository. 4904.
https://ir.lib.uwo.ca/etd/4904