Electronic Thesis and Dissertation Repository

Degree

Master of Science

Program

Microbiology and Immunology

Supervisor

Dr. Alp Sener

Abstract

Prolonged urinary obstruction can lead to renal dysfunction and irreversible injury. The recovery of renal function following decompression is heavily dependent on the degree of renal injury. This suggests that treatments aimed at mitigating renal injury could improve the recovery of renal function following decompression. Previous studies have shown that hydrogen sulfide (H2S), an endogenous gasotransmitter, can reduce the histopathological markers of renal injury following unilateral ureteral obstruction (UUO). However, the effects of H2S on renal function following decompression is unknown. Using the UUO and reimplantation (UUO-R) model, we demonstrate that H2S accelerates the recovery of renal function following decompression and mitigates renal injury. In vitro, H2S attenuates the transforming growth factor beta 1-mediated epithelial-mesenchymal transition pathway by increasing the expression of inhibitory Smad7 and angiotensin II type 2 receptor. These data suggest that H2S could potentially be a novel therapeutic strategy to improve patient outcomes in urinary obstruction.

Available for download on Sunday, June 30, 2019


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