Daily Hydrogen Sulfide Treatment Enables Early Recovery of Renal Function and Mitigates Renal Injury Following the Relief of Prolonged Urinary Obstruction

Author

Shouzhe Lin, The University of Western OntarioFollow

Degree

Master of Science

Program

Microbiology and Immunology

Supervisor

Dr. Alp Sener

Abstract

Prolonged urinary obstruction can lead to renal dysfunction and irreversible injury. The recovery of renal function following decompression is heavily dependent on the degree of renal injury. This suggests that treatments aimed at mitigating renal injury could improve the recovery of renal function following decompression. Previous studies have shown that hydrogen sulfide (H₂S), an endogenous gasotransmitter, can reduce the histopathological markers of renal injury following unilateral ureteral obstruction (UUO). However, the effects of H₂S on renal function following decompression is unknown. Using the UUO and reimplantation (UUO-R) model, we demonstrate that H₂S accelerates the recovery of renal function following decompression and mitigates renal injury. In vitro, H₂S attenuates the transforming growth factor beta 1-mediated epithelial-mesenchymal transition pathway by increasing the expression of inhibitory Smad7 and angiotensin II type 2 receptor. These data suggest that H₂S could potentially be a novel therapeutic strategy to improve patient outcomes in urinary obstruction.

Recommended Citation

Lin, Shouzhe, "Daily Hydrogen Sulfide Treatment Enables Early Recovery of Renal Function and Mitigates Renal Injury Following the Relief of Prolonged Urinary Obstruction" (2017). Electronic Thesis and Dissertation Repository. 4605.
https://ir.lib.uwo.ca/etd/4605