Electronic Thesis and Dissertation Repository

Degree

Master of Science

Program

Health and Rehabilitation Sciences

Supervisor(s)

Dr. Dianne Bryant & Dr. Kevin Willits

Abstract

The purpose of this study was to determine whether there is evidence to support conducting a larger randomized control trial (RCT) to compare the non-operative treatment of Achilles tendon (AT) ruptures with or without Autologous Conditioned Plasma (ACP®). Twenty-four patients were randomized to receive an ACP® or saline injection within seven days and again at two weeks post-rupture. Tendon healing was longitudinally evaluated using ultrasound (US) and magnetic resonance imaging (MRI). Functional and patient-reported quality of life measures were also assessed. A small sample size limited our ability to detect statistically significant differences. The mean rankings of healing were slightly higher in the ACP® group at most time points for MRI and US. Functional and patient-reported outcomes were also slightly higher in the ACP® group at most time points. The consistency of these preliminary results suggests that there is evidence to support conducting a larger RCT.


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