Electronic Thesis and Dissertation Repository

Degree

Master of Science

Program

Surgery

Supervisor

Dr. Abdel-Rahman Lawendy

Abstract

Acute limb compartment syndrome (ACS) causes a unique form of limb ischaemia, which induces intense inflammatory response resulting in microcirculatory dysfunction, neutrophil activation and cell injury. Increased intracompartmental pressure is the hallmark of ACS. Decompression by fasciotomy is the gold standard treatment. While fasciotomy saves the limb from ischaemic threat, paradoxically, it causes further damage to the muscle by reperfusion injury. In addition, it does not address the inflammatory element purported to increase the tissue injury in ACS.

Recent evidence suggests that hydrogen sulfide (H2S) can mitigate the damage associated with ischaemia-reperfusion injury. The purpose of this thesis was to examine the value of H2S treatment in a rat model of ACS, using GYY4137 as H2S-releasing molecule. We have demonstrated significant cytoprotective role of H2S on the skeletal muscle following ACS.

These results suggest a potential therapeutic value of H2S as an adjunctive to fasciotomy, for patients suffering ACS.


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