Master of Science
Dr. Earl Noble
Exercise induces cytoprotective stress proteins in blood vessels (BV) and skeletal myofibres. The localization and extent of induction with different exercise intensities is unclear. Rats (n=10 per group) were run at high (HIEX; 30m/min) versus low-intensity exercise (LOEX; 15m/min) for 1hr, sacrificed 24hr later. Sections of the white portion of the vastus were immunofluorescently stained for Hsp70 and Hsp90. It was hypothesized that: 1) a greater abundance of Hsp70 and Hsp90 would be observed in BVs following HIEX, 2) due to earlier recruitment, larger BVs would have a more robust response than small BVs, 3) more myofibres surrounding BVs expressing Hsp70 would express Hsp70. Ratio of BVs with Hsp70/total vessels and Hsp70 density was greater in HIEX versus LOEX (p
Kowalchuk, Hana, "The effects of acute high- and low-intensity exercise on Hsp70 and Hsp90 accumulation in rat skeletal myofibres and vasculature" (2013). Electronic Thesis and Dissertation Repository. 1604.