Reduction of Esters to Ethers Utilizing the Powerful Lewis Acid BF2OTf·OEt2
Brian Pagenkopf, University of Western OntarioFollow
Nicholas A. Morra
The direct reduction of esters to their corresponding ethers has been achieved using the Lewis acid BF2OTf·OEt2 generated via anionic redistribution between TMSOTf and BF3·OEt2 with triethylsilane acting as the reducing agent. Isolated yields of up to 71% have been obtained with the corresponding alcohol as the only side product.
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