Chemistry Publications

Document Type

Article

Publication Date

6-9-2009

Journal

Organic letters

Volume

11

Issue

13

First Page

2780

Last Page

2783

Abstract

A concise method for the synthesis of several tetrahydroisoquinocarbazole derivatives is reported, where the core is prepared in six steps from tryptophol in 51% overall yield. The pentacyclic analogs are constructed via a dipolar C-2 alkylation of a 3-substituted indole with a 2-alkoxycyclopropanoate ester and a SmBr(2)-HMPA mediated ketyl-alkene ring closure.


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