Chemistry Publications

Document Type

Article

Publication Date

6-15-2010

Journal

Organic letters

Volume

12

Issue

14

First Page

3168

Last Page

3171

URL with Digital Object Identifier

10.1021/ol101078z

Abstract

A new method for the synthesis of 5-azaindole derivatives is reported. A [3+2] dipolar cycloaddition between nitriles and a 3,4-cyclopropanopiperidine followed by SeO(2) oxidation affords the target compounds in moderate to excellent yields. The divergent nature and cost effectiveness of this method makes it very suitable for combinatorial applications in the pharmaceutical industry.


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