Chemistry Publications

Document Type

Article

Publication Date

10-2015

Journal

Tetrahedron Letters

Volume

56

Issue

44

First Page

6052

Last Page

6055

URL with Digital Object Identifier

http://dx.doi.org/10.1016/j.tetlet.2015.09.064

Abstract

The synthesis of 2,5,5-trisubstituted tetrahydrofuran rings was accomplished via the Mukaiyama aerobic oxidative cyclization of tertiary 5-pentenols employing the Co(nmp)2catalyst. A variety of THFs were formed in moderate to good yield and diastereoselectivity. The method developed herein was successfully applied to an enantioselective total synthesis of cyclocapitelline.


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