Synthesis of (+)-Bovidic Acid

Authors

Geoffrey A. Phillips
Timothy B. Wright
Andrew C. Stevens
Brian Pagenkopf, University of Western OntarioFollow

Document Type

Article

Publication Date

8-29-2014

Journal

Canadian Journal of Chemistry

Volume

93

Issue

2

First Page

196

Last Page

198

URL with Digital Object Identifier

http://www.nrcresearchpress.com/doi/abs/10.1139/cjc-2014-0288

Abstract

(+)-Bovidic acid is an 18-carbon hydroxyfuranoid acid isolated from the pelage of the gaur (Bosfrontalis) and displays potential as an insect repellant. Both a formal and total synthesis of (+)-bovidic acid was carried out with the core of the natural product being synthesized through Mukaiyama aerobic oxidative cyclization employing the second-generation Co(nmp)₂ catalyst.