Title

Synthesis of MRI Contrast Agents Derived from DOTAM-Gly-L-Phe-OH Incorporating a Disulfide Bridge: Conjugation to a Cell Penetrating Peptide and Preparation of a Dimeric Agent

Document Type

Article

Publication Date

9-15-2010

Journal

Bioorganic & Medicinal Chemistry Letters

Volume

20

Issue

18

First Page

5521

Last Page

5526

URL with Digital Object Identifier

http://dx.doi.org/10.1016/j.bmcl.2010.07.070

Abstract

A cell penetrating peptide conjugate and dimeric PARACEST MRI contrast agents, based on the DOTAM-Gly-L-Phe-OH scaffold have been prepared in moderate yields using diethyl azodicarboxylate (DEAD) or iodine-mediated disulfide bridge formation as a key step. Magnetic (PARACEST) properties of these agents have been evaluated.