Chemical and Biochemical Engineering Publications Copyright (c) 2013 Western University All rights reserved. http://ir.lib.uwo.ca/chemengpub Recent documents in Chemical and Biochemical Engineering Publications en-us Sat, 26 Jan 2013 23:30:01 PST 3600 Modification of Polymer Networks with Bone Sialoprotein Promotes Cell Attachment and Spreading http://ir.lib.uwo.ca/chemengpub/1 http://ir.lib.uwo.ca/chemengpub/1 Mon, 06 Dec 2010 18:33:23 PST Biomaterials used for tissue engineering scaffolds act as temporary substrates, on which cells deposit newly synthesized extracellular matrix. In cartilage tissue engineering, polycaprolactone/poly(2-hydroxyethyl methacrylate) (PCL/pHEMA) polymer blends have been used as scaffold materials, but their use in osseous tissue engineering has been more limited. The objective of this study was to evaluate modification of PCL/pHEMA surfaces with bone sialoprotein (BSP), an extracellular matrix protein important in regulating osseous tissue formation. Modification of surfaces with BSP significantly enhanced osteoblastic cell attachment and spreading, without compromising proliferation. Thus, BSP-immobilization may be a useful strategy for optimizing scaffolds for skeletal tissue engineering.

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