2024-03-29T01:48:24Z
http://ir.lib.uwo.ca/do/oai/
oai:ir.lib.uwo.ca:oncpres-1005
2009-11-07T04:07:08Z
publication:physicspres
publication:biophysicspres
publication:physics
publication:rwkex_posterpresentations
publication:medimagingpres
publication:medimaging
publication:faculties
publication:oncpres
publication:rwkex
publication:robartspres
publication:biophysics
publication:robarts
publication:surgery
publication:surgerypres
publication:institutes
publication:onc
Robot Assisted Ultrasound Imaged Guided Interstitial Lung Brachytherapy in a Porcine Model
Malthaner, Richard A.
Yu, Edward
Battista, Jerry J.
Blake, Chris
Downey, Donal
Fenster, Aaron
We set out to see if permanent interstitial brachytherapy seeds could be safely and reproducibly inserted thoracoscopicaly with the ZEUS Robotic system and intraoperative ultrasound into in-vivo porcine lungs.
2005-01-01T08:00:00Z
presentation
application/pdf
https://ir.lib.uwo.ca/oncpres/6
https://ir.lib.uwo.ca/context/oncpres/article/1005/viewcontent/Yu__malthaner_robot_bracytherapy_cars_2005_05_07.pdf
Oncology Presentations
Scholarship@Western
Brachytherapy
Interstitial Lung
Robot Assisted
Ultrasound
Bioimaging and Biomedical Optics
Oncology
Surgery
oai:ir.lib.uwo.ca:oncpres-1002
2009-11-07T02:52:45Z
publication:biophysicspres
publication:rwkex_posterpresentations
publication:epidempres
publication:faculties
publication:oncpres
publication:rwkex
publication:biophysics
publication:epidem
publication:surgery
publication:surgerypres
publication:onc
The Role of Radiation Therapy on Medically Inoperable Clinically Localized Non-small Cell Lung Patients: London Regional Cancer Program (LRCP) Clinical Experience
Lee, Michael
Yu, Edward
Ash, Robert
Tai, Patricia
Stitt, Larry
Rodrigues, George
Dar, Rashid
Vincent, Mark
Inculet, Richard
Malthaner, Richard
Lung cancer is the most frequent cause of cancer death in both men and women in North America. In 2006, an estimated 22,700 Canadians will be diagnosed with lung cancer and 19,300 will die of it (Canadian Cancer Statistics 2006).
Approximately 15-20% of NSCLC patients present with early or localized disease.
Surgical resection of T1-2N0 NSCLC remains the treatment of choice for this population, and results in a 5-year survival rate of 50-70%.
Patients deemed medically inoperable have been treated with non-surgical therapies, such as radiation therapy(RT), while some patients have simply been observed without any tumor therapy because of their co-morbid illnesses.
Potential confounding issues in this patient population include some patients who are not referred to our Centre due to co-morbid disease, and some who are referred, but are not offered radical RT due to poor outcome expectations. In addition, patients may refuse treatment when offered.
We have reviewed thepast 19 years’ experience at LRCP inmanagement of this group of patients.
2006-01-01T08:00:00Z
presentation
application/pdf
https://ir.lib.uwo.ca/oncpres/3
https://ir.lib.uwo.ca/context/oncpres/article/1002/viewcontent/Yu__Lee_UWO_Research_Day_CARO_2006_poster_Final.pdf
Oncology Presentations
Scholarship@Western
Radiation Therapy
London Regional Cancer Program
lung cancer
Epidemiology
Oncology
Surgery
oai:ir.lib.uwo.ca:oncpres-1001
2009-11-07T02:28:36Z
publication:biophysicspres
publication:rwkex_posterpresentations
publication:faculties
publication:oncpres
publication:rwkex
publication:biophysics
publication:onc
Evaluation of Intra-and Inter-fraction Motion in Breast Radiotherapy Using Electronic Portal Imaging Cine Loops
Lee, Chrison
Yu, Edward
Kron, Tomas
Parallel tangent breast irradiation is commonly used postbreast conservation surgery for early breast cancer patient without lymph node involvement to improve local disease control. Intra-fractional and inter-fractional variabilities are often presented in daily treatment setup. The present pilot study used Electronic Portal Imaging (EPI) to evaluate intra-and inter-fraction motion in patients undergoing simple breast tangent radiotherapy.
2003-01-01T08:00:00Z
presentation
application/pdf
https://ir.lib.uwo.ca/oncpres/2
https://ir.lib.uwo.ca/context/oncpres/article/1001/viewcontent/Yu__EY_CARO_poster_oct_2003_final_version.pdf
Oncology Presentations
Scholarship@Western
breast radiotherapy
Electronic Portal Imaging
Bioimaging and Biomedical Optics
Oncology
oai:ir.lib.uwo.ca:oncpres-1004
2009-11-07T03:41:13Z
publication:biophysicspres
publication:medimagingpres
publication:rwkex_researcharticles
publication:epidempres
publication:medimaging
publication:faculties
publication:oncpres
publication:rwkex
publication:biophysics
publication:epidem
publication:surgery
publication:surgerypres
publication:onc
Is Extended Volume of External Beam Irradiation Beneficial in Post-esophagectomy High Risk Patients Receiving Combined Chemoradiation Therapy?
Yu, E.
Dar, A. R.
Ash, R.
Videtic, G.
Truong, P.
Stitt, L.
Tomiak, A.
Vincent, M.
Malthaner, R.
Craig, I.
Brecevic, E.
Kocha, W.
Inculet, R.
Lefcoe, M.
OBJECTIVE: To assess the value of extended volume irradiation with anastomotic coverage in high risk resected esophageal cancer patients.
METHOD: A retrospective study was undertaken at LRCC from 1989-1999 for high risk resected esophageal cancer patients. Adjuvant treatments consisted of 4 cycles of chemotherapy (epirubicin/fluorouracil/cisplatin or cisplatin/fluorouracil), and local regional irradiation with or without coverage of the anastomotic site. Radiation dose ranged from 45-60Gy at 1.8-2.0 Gy/fraction given with initial anterior-posterior/posterior-anterior arrangement with either extended (with anastomotic coverage) or small (without anastomotic coverage) field followed by oblique fields for boost.
RESULT: One hundred eighty-eight charts were reviewed. Seventy-two patients were eligible for post-resection chemoradiation therapy. Three patients had disease progression prior to therapy, and 69 patients were analyzed. There were 81% T3N1 and 13% T2N1. Thirty-four patients had margin involvements (radial 53%; proximal/distal 32%), 65% were adenocarcinoma and 33% were squamous carcinoma. Median followup was 23.6 months (3.4 - 78.4 months). Two year survival was 50%; 5yr 24%. Relapse rate was 62.3% and median time to relapse was 20 months. Recurrence locally to anastomosis or adjacent to anastomosis was 9/43(20.9%) with small field and 2/26(7.7%) with extended field. Of 31 patients with relapse outside anastomosis, 14/20(70%) relapsed locoregional/distal when treated with small field and 3/11(27%) relapsed locoregional/distal when treated with extended field (p=0.02). There was no excess treatment interruption or chronic gastrointestinal toxicity with extended field irradiation.
CONCLUSION: There is significant decrease in locoregional/distal relapse with use of extended field in high risk resected esophageal cancer patients.
2001-01-01T08:00:00Z
presentation
application/pdf
https://ir.lib.uwo.ca/oncpres/5
https://ir.lib.uwo.ca/context/oncpres/article/1004/viewcontent/Yu__CARO_poster___esophagus_2001.pdf
Oncology Presentations
Scholarship@Western
irradiation
esophageal cancer
esophagectomy
chemoradiation therapy
Bioimaging and Biomedical Optics
Oncology
Surgery
oai:ir.lib.uwo.ca:oncpres-1000
2009-11-07T02:14:37Z
publication:biophysicspres
publication:rwkex_posterpresentations
publication:epidempres
publication:faculties
publication:oncpres
publication:rwkex
publication:biophysics
publication:epidem
publication:surgery
publication:surgerypres
publication:onc
Post-Operative Extended Volume External Beam Radiation Therapy Is Safe for High Risk Esophageal Cancer Patients
Yu, Edward
Tai, Patricia
Younus, Jawaid
Malthaner, Richard
Stitt, Larry
Truong, Pauline
Rodrigues, George
Ash, Robert
Dar, Rashid
Tomiak, Anna
Vincent, Mark
Kocha, Walter
Dingle, Brian
Inculet, Richard
Post-operative radiation therapy (RT) (1) and post-operative chemoradiation (2) have been used for esophageal cancer patients deemed high risk for recurrence after esophagectomy.
Defining opitmal RT target volume after esophagectomy is difficult due to significant changes in patient anatomy and function.
Some radiationon cologists advocated the inclusion of the anastomotic site within the irradiation volume due to concerns for potential increased relapse risk, while others did not subscribe to this practice due to concerns for increased treatment related toxicity.
We have previously reported patient outcome benefit using extended volume RT In management with high risk esophageal cancer patients underwent esopagectomy(3).
We have performed a Phase I study to evaluate the safety of subscription to this practice.
(1). Folk et al, Surgery, 113:1993
(2). Bedard et al, Cancer, 91;2001
(3). Yu et al, Radiother & Oncol, 73;2004
2007-01-01T08:00:00Z
presentation
application/pdf
https://ir.lib.uwo.ca/oncpres/1
https://ir.lib.uwo.ca/context/oncpres/article/1000/viewcontent/Yu__Edward_Yu_CARO_2007finalversion_poster.pdf
Oncology Presentations
Scholarship@Western
Radiation Therapy
Esophageal Cancer
Epidemiology
Oncology
Surgery
oai:ir.lib.uwo.ca:oncpres-1003
2009-11-07T03:26:33Z
publication:biophysicspres
publication:rwkex_posterpresentations
publication:epidempres
publication:faculties
publication:oncpres
publication:rwkex
publication:biophysics
publication:epidem
publication:surgery
publication:surgerypres
publication:onc
Extended vs. Small Field Irradiation in High Risk Post Esophagectomy Patients Receiving Combined Chemoradiation Therapy: A Decade Experience in Treatment of Esophageal Cancer
Yu, Edward
Tai, Patricia
Rodrigues, George
Ash, Robert
Stitt, Larry
Dar, Rashid A.
Truong, Pauline
Videtic, Gregory M.
Malthaner, Richard
Inculet, Richard
Tomiak, Anna
Younus, Jawaid
Dingle, Brian
Kocha, Walter
Vincent, Mark
OBJECTIVE: To assess the impact of extended field irradiation with anastomotic coverage on local recurrence in high risk resected esophageal cancerpatients.
METHODS: From 1989-1999, high risk resected esophageal cancer cases receiving post-resection chemoradiation were reviewed. Adjuvant chemotherapy consisted of four cycles of fluorouracil-based regimens. Loco-regional irradiation with or without coverage of anastomotic site had radiation a dose range from 45-60 Gyat 1.8-2.0 Gy/fraction given with initial anterior-posterior/posterior-anterior arrangement with either extended (with anastomotic coverage), or small (without anastomotic coverage) field followed by oblique fields for boost.
RESULTS: One hundred eighty-eight charts were reviewed. Seventy-two patients were eligible for post-resection chemoradiation. Three patients had disease progression prior to therapy, and 69 patients were analyzed. The median age was 60 years (range 35-82 years) with 94% T2-3N1 and 65% were adenocarcinoma. As of January 2005 median followup was 30.5 months (range 3-142 months), the two-and five-year overall survival rates were 50% and 31%, respectively. First relapse rate after adjuvant therapy was 71% (n=49) and median time to relapse was about 30 months. Loco-regional relapse with small field was 25/35 (71.4%) and 2/14 (14.2%) with extended field (P<0.001). Recurrence locally to anastomosis or adjacent site was 10/35 (28.6%) with small field and 0/14 (0%) with extended field (P=0.04).
CONCLUSION: At a minimum of 5-year followup, there is significant decrease in loco-regional relapse with the use of extended field in high risk resected esophageal cancer patients. This important improvement trend deserves further exploration in prospective randomized clinical trials.
2005-01-01T08:00:00Z
presentation
application/pdf
https://ir.lib.uwo.ca/oncpres/4
https://ir.lib.uwo.ca/context/oncpres/article/1003/viewcontent/Yu__esophagectomy_poster_final_version_fall_2005.pdf
Oncology Presentations
Scholarship@Western
irradiation
esophageal cancer
esophagectomy
chemoradiation therapy
Epidemiology
Oncology
Surgery
oai:ir.lib.uwo.ca:oncpres-1006
2010-01-26T22:27:35Z
publication:biophysicspres
publication:rwkex_powerpointposters
publication:epidempres
publication:faculties
publication:oncpres
publication:rwkex
publication:biophysics
publication:epidem
publication:surgery
publication:surgerypres
publication:onc
What Factors Predict Outcome at Relapse after Previous Esophagectomy and Adjuvant Therapy in High-Risk Esophageal Cancer?
Yu, Edward
Tai, Patricia
Malthaner, Richard
Stitt, Larry
Rodrigues, George
Dar, Rashid
Yaremko, Brian
Younus, Jawaid
Sanatani, Michael
Vincent, Mark
Dingle, Brian
Fortin, Dalilah
Inculet, Richard
Management of patients who have disease relapse after completion of surgery and adjuvant chemo-radiation (CRT) is controversial.
Some oncologists would advocate intensive therapeutic intervention due to promising experience on treatment for recurrence disease while others would recommend palliative support due to the concerns for poor patient outcome post disease recurrence.
In Addition, it is not clear if patient outcome is improved post adjuvant CRT when patients at risk have resection margin involvement and if time interval to recurrence can affect patient survival post relapse.
The present study was conducted to determine what factors will affect patient outcome at relapse after previous surgery and adjuvant CRT in high-risk esophageal cancer patients
This clinical information may be useful in providing appropriate guidance for oncologists to manage esophageal cancer patients after disease relapse.
2009-10-01T07:00:00Z
presentation
application/vnd.ms-powerpoint
https://ir.lib.uwo.ca/oncpres/7
https://ir.lib.uwo.ca/context/oncpres/article/1006/type/native/viewcontent/Thoracic_Conference_R_E_CARO_E._Yu.ppt
Oncology Presentations
Scholarship@Western
Esophagectomy
Adjuvant Therapy
Esophageal Cancer
Epidemiology
Oncology
Surgery
oai:ir.lib.uwo.ca:oncpres-1007
2011-06-09T06:40:33Z
publication:rwkex_videoawardpresentation
publication:faculties
publication:oncpres
publication:rwkex
publication:onc
Hellmuth Award Public Lecture by Ann Chambers
Chambers, Ann
2011-05-01T07:00:00Z
lecture
https://ir.lib.uwo.ca/oncpres/8
http://www.youtube.com/watch?v=Y4y7BzIY1-g
Oncology Presentations
Scholarship@Western
Cancer
Breast cancer
Metastasis
Ann Chambers
Oncology
oai:ir.lib.uwo.ca:oncpres-1010
2017-03-03T17:43:36Z
publication:rwkex_researcharticles
publication:faculties
publication:oncpres
publication:rwkex
publication:onc
Thurs Eve23: Effect of lung density and geometry variation on inhomogeneity correction algorithms: A Monte Carlo dosimetry evaluation
Chow, J
Leung, Michael
Van Dyk, Jacob
This study provides new information on the evaluation of the lung dose calculation algorithms as a function of the relative electron density of lung, ρe,lung. Doses calculated using the collapsed cone convolution (CCC) and adaptive convolution (AC) algorithm in lung with the Pinnacle3 system were compared to those calculated using the Monte Carlo(MC) simulation (EGSnrc‐based code). Three groups of lung phantoms, namely, “Slab”, “Column” and “Cube” with different ρe,lung (0.05–0.7), positions, volumes and shapes of lung in water were used. 6 and 18MV photon beams with 4×4 and 10×10cm2field sizes produced by a Varian 21EX Linac were used in the MC dose calculations. Results show that the CCC algorithm agrees well with AC to within ±1% for doses calculated in the lung phantoms, indicating that the AC, with 3–4 times less computing time required than CCC, is a good substitute for the CCC method. Comparing the CCC and AC with MC, dose deviations are found when ρe,lung are ⩽0.1–0.3. The degree of deviation depends on the photon beam energy and field size, and is relatively large when high‐energy photon beams with small field are used. For the penumbra widths (20%–80%), the CCC and AC agree well with MC for the “Slab” and “Cube” phantoms with the lung volumes at the central beam axis (CAX). However, deviations >2mm occur in the “Column” phantoms, with two lung volumes separated by a water column along the CAX, using the 18MV (4×4cm2) photon beams with ρe,lung ⩽0.1.
2008-07-01T07:00:00Z
presentation
https://ir.lib.uwo.ca/oncpres/9
info:doi/10.1118/1.2965942
http://dx.doi.org/10.1118/1.2965942
Oncology Presentations
Scholarship@Western
Lung density
dose calculation
collapsed cone convolution
CCC
geometry variation
oncology
Medical Biophysics
Oncology
oai:ir.lib.uwo.ca:oncpres-1009
2017-03-03T17:35:01Z
publication:rwkex_researcharticles
publication:faculties
publication:oncpres
publication:rwkex
publication:onc
Wed Eve—45: Imaging and Radiation Delivery in Helical Tomotherapy: Phantom Study of a Moving Target
Gallagher, C
Yartsev, Slav
Gaede, Stewart, PhD, MCCPM
Van Dyk, Jacob
Radiation is an effective method of treating lung cancer, however, the tumour moves while the patient breathes. To ensure radiation always covers the tumour, a volume larger than the target must be treated. For conventional treatments, gating can be employed, but helical tomotherapy treatments cannot be gated. We hypothesized that, through judicious choice of planning computed tomography (CT) imaging methods, radiation can be accurately planned and delivered to a moving tumour using tomotherapy. A breathing phantom was used which allowed one-dimensional motion of a lung-equivalent cylinder containing a target. By varying the imaging parameters, we obtained numerous different planning studies with target motion in both the superior-inferior and lateral directions. These studies included a static study, fast-CT studies, a maximum intensity projection (MIP), an average intensity projection (AveIP) and an untagged average study. Planning studies were acquired with the cylinder moving sinusoidally with a period of 4 s and amplitude of 1 cm. Treatment plans were created for each CT study and delivered using tomotherapy. Dose was measured using self-developing film. Dose-area histograms were used to compare the dose delivery to the central coronal plane of the target for all planning studies. A similar experiment was also performed using an irregular breathing pattern. Results indicated that planning using the AveIP study results in the most accurate treatment of a moving target. The amount of dose delivered to the normal tissue did not change significantly, due to the small increase in irradiated area compared to the entire area of the film.
2009-09-01T07:00:00Z
presentation
https://ir.lib.uwo.ca/oncpres/10
info:doi/10.1118/1.3244149
http://dx.doi.org/10.1118/1.3244149
Oncology Presentations
Scholarship@Western
Helical Tomotherapy
Imaging
CT
Radiation
Oncology
Medical Biophysics
Oncology