Title

The Expression of Toll-like Receptors 2, 4, 5, 7 and 9 in Merkel Cell Carcinoma.

Document Type

Article

Publication Date

4-1-2015

Journal

Anticancer research

Volume

35

Issue

4

First Page

1843

Last Page

1849

URL with Digital Object Identifier

doi: 10.1002/jmri.24659

Abstract

AIM: We sought to clarify whether the expression of toll-like receptors (TLR) in Merkel cell carcinoma (MCC) is linked to tumor and patient characteristics, especially the presence of Merkel cell polyoma virus (MCV).

MATERIALS AND METHODS: The study comprised of 128 patients with data on Merkel cell polyomavirus (MCV) status and clinical features were included in the study. Immunohistochemistry for TLR expression was performed on tissue microarray (TMA) slides.

RESULTS: TLR 2, 4, 5, 7 and 9 expression was noted in most of the tumor specimens. Decreased expression of TLR 9 correlated strongly with MCV positivity. Cytoplasmic TLR 2 expression correlated with small tumor size, while nuclear TLR 2 and TLR 5 expressions with larger tumors. Increased nuclear TLR 4 expression and decreased TLR 7 expression were associated with older age.

CONCLUSION: TLR 2, 4, 5, 7 and 9 appear to reflect certain clinicopathological variables and prognostic markers of MCC tumors.